Ye, Shun, Suja, Vinny Chandran, Li, Chenlong, Jiang, Chongming, Zamani, Reza, Li, Xiang, Bain, Christopher, Zhou, Yuqi, Peterson, Walker, Wang, Huidong, Hu, Chenglang, Park, Jongchan, Cheng, Xiao, Swedlund, Benjamin, Murillo, Sandra, Sivanandan, Anjali, Sun, Shiyu, Lanfeng, Liang, Islam, Mohammad Tariqul, Joy, Baju C., Khan, Ishaq N., Kumar, Sreedhar S., Mercado-Vásquez, Gabriel, Vizzard, James V., Matthews, Jonathan M., Huang, Helen, Guo, Xiaolu, Nicklow, Ethan, Chen, Guorui, Neff, Ryan A., Maity, Surjendu, Park, Hyeonjin, Joo, Han-ho, Dong, Katherine, Cai, Yuyan, Huang, Weihang, Zou, Yichen, Yan, Rui, Figueroa, Raphael, Goncharov, Artem, Schremmer, Bella Rose, Linton, Lian Elsa, Goda, Keisuke, Gao, Liang, Cheng, Ke, Morsut, Leonardo, Wilson, Jennifer L., Fu, Jianping, Teck, Lim Chwee, Sarkar, Deblina, Hierlemann, Andreas, Tay, Savaş, Hoffmann, Alexander, Griffin, Donald Richieri, Chen, Jun, Kelley, Shana O., Varghese, Shyni, Cheon, Jinwoo, Lam, Wilbur A., Moon, James J., Wong, Wilson W., Mitragotri, Samir, Di Carlo, Dino
Abstract
Large Language Models (LLMs) have demonstrated historic breakthroughs in general reasoning with early successes in biomedical science. However, existing LLM benchmarking emphasizes factual recall, offering limited insight into model performance on frontier and multimodal tasks. We assembled BioEVAL (BioEngineering Validation of AI and LLMs), a global, multi-institutional initiative designed to assess experimental reasoning capability across bioengineering (BE) subfields. BioEVAL spans 11 major BE subfields plus a set of uncategorized items, bringing together 22 research groups to create a PhD-level benchmark comprising 608 evaluation items: 1) 380 multiple-choice questions (MCQs, 359 retained after audit), 2) 218 literature synthesis tasks, and 3) 10 multimodal problems with experimental image interpretation. Benchmark items underwent authoring-group expert review and centralized quality control before evaluation. Following evaluation, a blinded cross-group consensus audit of the highest- and lowest-accuracy MCQ items flagged 21 questions for revision or removal; these were withheld, and all reported MCQ results are computed on the 359 retained items. We evaluated diverse cloud-scale foundation/multimodal models (e.g., ChatGPT, Gemini, and Grok) and locally deployable models suitable for inference on consumer-grade GPUs. Models achieved the highest accuracy of up to 90% on MCQs, similarity score of 0.72 on literature synthesis, and accuracy of 80% on a small sample of multimodal reasoning questions, with substantial performance variation across subfields. Leaderboard rankings characterize current capabilities, limitations, and development priorities across the evaluated BE task categories. BioEVAL is maintained as an extensible benchmark with standardized protocols for continuing expert item contribution and model evaluation.
Chinese Translation
大型语言模型(LLMs)在一般推理方面取得了历史性的突破,并在生物医学科学领域取得了早期成功。然而,现有的LLM基准测试强调事实回忆,提供的关于模型在前沿和多模态任务上的表现的见解有限。我们组建了BioEVAL(生物工程人工智能与LLMs验证),这是一个全球多机构的倡议,旨在评估生物工程(BE)子领域的实验推理能力。BioEVAL涵盖了11个主要的BE子领域以及一组未分类项目,汇集了22个研究小组,创建了一个包含608个评估项目的博士级基准:1)380个多项选择题(MCQs,审计后保留359个),2)218个文献综合任务,以及3)10个具有实验图像解释的多模态问题。基准项目在评估前经过作者小组的专家审查和集中质量控制。在评估后,对最高和最低准确度的MCQ项目进行了盲审,标记出21个问题以供修订或删除;这些问题被保留,所有报告的MCQ结果均基于359个保留项目进行计算。我们评估了多种云规模的基础/多模态模型(例如,ChatGPT、Gemini和Grok)以及适合在消费级GPU上进行推理的本地可部署模型。模型在MCQs上达到了最高90%的准确率,在文献综合上的相似度得分为0.72,在少量多模态推理问题上的准确率为80%,不同子领域之间的表现差异显著。排行榜排名表征了当前在评估的BE任务类别中的能力、局限性和发展优先级。BioEVAL作为一个可扩展的基准,保持标准化协议,以便持续进行专家项目贡献和模型评估。